3-amino-2-aryl quinuclidines

Details 3-amino-2-aryl quinuclidines 3-amino-2-aryl quinuclidines

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2084193

Compound of formula (1), wherein R1 is hydrogen or (C1-C6)alkyl; R2 is phenyl, pyridyl, thienyl or furyl, and R2 may optionally be substituted with from one to three substituents independently selected from (C1-C4)alkyl, (C1-C4)alkoxy, chloro, fluoro, bromo, iodo, and trifluoromethyl; R3 is phenyl. naphthyl, pyridyl, thienyl or furyl, and R3 may optionally be substituted with from one to three substituents independently selected from (C1-C4)alkyl, (C1-C4)alkoxy, chloro, fluoro, bromo, iodo and trifluoromethyl; and the pharmaceutically acceptable salts of such compounds. These compounds are substance antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.

Composé de formule (1), où R1 est de l'hydrogène ou un alkyle (C1-C6); R2 est un phényle, pyridyle, thiényle ou furyle; R2 peut être facultativement avec substitution par un à trois groupes choisis chacun indépendamment l'un de l'autre parmi un alkyle (C1-C4), alcoxy (C1-C4), chloro, fluoro, bromo, iodo et trifluorométhyle; R3 est un phényle, naphtyle, pyridyle, thiényle ou furyle; R3 peut être facultativement avec substitution par un à trois groupes choisis chacun indépendamment l'un de l'autre parmi un alkyle (C1-C4), alcoxy (C1-C4), chloro, fluoro, bromo, iodo et trifluorométhyle; enfin, les sels de ces composés, acceptables en pharmacie. Ces composés sont des antagonistes et se révèlent utiles pour le traitement de troubles gastro-intestinaux et inflammatoires, ainsi que de problèmes et de douleurs dans le système nerveux central.

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