3-aryl-pyrrolidine-2,4-dione derivatives

Details 3-aryl-pyrrolidine-2,4-dione derivatives 3-aryl-pyrrolidine-2,4-dione derivatives

C - Chemistry, Metallurgy

07

D

167/211, 167/233

C07D 207/36 (2006.01) A01N 43/36 (2006.01) A01N 47/06 (2006.01) A61K 31/40 (2006.01) C07D 207/38 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2007239

Abstract The invention relates to new 3-aryl-pyrrolidine-2,4-dione derivatives, which are represented by the formula (I) Image (I) in which X represents alkyl, halogen and alkoxy, Y represents hydrogen, alkyl, halogen, alkoxy and halogenoalkyl, Z represents alkyl, halogen and alkoxy, n represents a number from 0-3, R represents hydrogen or represents the groups -CO-R1, -CO-O-R2 in which R1 represents alkyl, alkenyl, alkoxyalkyl, alkyl- thioalkyl, polyalkoxyalkyl and cycloalkyl which can be interrupted by hetero atoms, each of which radicals is optionally substituted by halogen, or represents optionally substituted phenyl, option- ally substituted phenylalkyl, substituted het- aryl, substituted phenoxyalkyl and substituted hetaryloxyalkyl, and R2 represents alkyl, alkenyl, alkoxyalkyl, polyalk- oxyalkyl and optionally substituted phenyl or cyclo- alkyl, each of which radicals is optionally substituted by halogen, Le A 26 556- A represents alkyl, alkenyl, alkinyl, alkoxyalkyl, polyalkoxyalkyl, alkylthioalkyl, or cycloalkyl which is optionally interrupted by hetero atoms, each of which radicals is optionally substituted by halogen, or represents arylalkyl which is optionally sub- tituted by halogen, alkyl, halogenoalkyl, alkoxy or nitro, B and C independently of one another represent hydrogen, alkyl or alkoxyalkyl, and the enantiomerically pure forms of compounds of the formula (I). Le A 26 556-

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