C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/42 (2006.01) A61K 31/4706 (2006.01) A61P 29/00 (2006.01) C07D 215/44 (2006.01)
Patent
CA 2608540
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
L'invention concerne des composés de formule (I): (I), et des sels pharmaceutiquement acceptables de ces composés, R1, R2, R3, R4, R5, R6, R7, R8, m et n étant comme définis dans la description. La présente invention porte également sur des procédés pour produire des composés de formule (I), et sur des méthodes pour traiter des maladies inflammatoires telles que la polyarthrite rhumatoïde chez un mammifère, par administration d'une quantité thérapeutiquement suffisante d'un composé de formule (I) au mammifère.
Condon Jeffrey Scott
Cuozzo John William
Gopalsamy Ariamala
Green Neal Jeffrey
Guler Satenig Y.
Torys Llp
Wyeth
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