3 -deazapurine derivatives as tlr7 modulators

Details 3 -deazapurine derivatives as tlr7 modulators 3 -deazapurine derivatives as tlr7 modulators

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2640672

The present invention relates to immune response modifiers of Formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.

La présente invention concerne des agents modifiant la réponse immunitaire de formule (I), qui agissent sélectivement par agonisme des récepteurs analogues à Toll (TLR, Toll-like receptor), leurs utilisations, des procédés pour les préparer, des intermédiaires utilisés pour les préparer et des compositions contenant lesdits inhibiteurs. Ces inhibiteurs sont utiles dans divers domaines thérapeutiques, parmi lesquels le traitement d'une maladie infectieuse telle que l'hépatite (par exemple HCV, HBV), une infection par un virus génétiquement apparenté et le cancer.

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