C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2402039
This invention is directed to 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives useful as .delta.-opioid or µ-opioid receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.
L'invention concerne des dérivés de 3-(diarylmethylène)-8-azabicyclo[3.2.1]octane utiles comme modulateurs du récepteur opioïde .delta. ou µ. Selon leur effet agoniste ou antagoniste, ces composés sont utiles comme analgésiques, immunosuppresseurs, agents anti-inflammatoires, agents destinés au traitement d'états neurologiques et psychiatriques, médicaments destinés à l'abus de drogues et d'alcool, agents destinés au traitement de la gastrite et de la diarrhée, agents cardio-vasculaires et agents destinés au traitement de maladies respiratoires.
Boyd Robert E.
Carson John R.
Coats Steven J.
Neilson Lou Anne
Pitis Philip M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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