3'-prodrugs of 2'-deoxy-.beta.-l-nucleosides

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 19/073 (2006.01) A61K 31/7068 (2006.01) A61P 31/12 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2413163

The present invention relates to compounds, compositions and methods for the treatment of a host infected with a hepatitis B virus. Specifically, compounds and compositions of 3'-esters of 2'-deoxy-.beta.-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti- hepatitis B agents. Compounds and compositions of 3',5'-esters of 2'-deoxy- .szlig.-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents, are also disclosed.

L'invention concerne des composés, des compositions et des procédés servant à traiter un hôte infecté par un virus de l'hépatite B. Spécifiquement, l'invention concerne des composés et des compositions de 3'-esters de 2'-désoxy-.szlig.-L-nucléosides, qui peuvent être administrés seuls ou combinés à d'autres agents anti-hépatite B. L'invention concerne aussi des composés et des compositions of 3',5'-esters de 2'-désoxy-.szlig.-L-nucléosides, qui peuvent être administrés seuls ou combinés à d'autres agents anti-hépatite B.

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