3-substituted-2-oxindole-1-carboxamides for suppressing...

Details 3-substituted-2-oxindole-1-carboxamides for suppressing... 3-substituted-2-oxindole-1-carboxamides for suppressing...

A - Human Necessities

61

K

167/240

A61K 31/40 (2006.01)

Patent

CA 1324762

3-SUBSTITUTED-2-OXINDOLE-1-CARBOXAMIDES FOR SUPPRESSING T-CELL FUNCTION ABSTRACT This invention relates to the use of certain 3-substituted-2-oxindole-1-carboxamides of the formula Image and the pharmaceutically-acceptable base salts thereof wherein X is H, Cl or F; Y is H or Cl; and R is benzyl or thienyl to suppress T-cell function in a mammal. This invention also relates to the use of such compounds for treating T-cell mediated autoimmune disorders of the systemic or organ specific type. The methods of this invention comprise administering a T-cell function suppressing amount of the compounds and salts of this invention to such a mammal.

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