¬4.2.0|bicyclooctane derivatives with valuable therapeutic...

Details ¬4.2.0|bicyclooctane derivatives with valuable therapeutic... ¬4.2.0|bicyclooctane derivatives with valuable therapeutic...

C - Chemistry, Metallurgy

07

C

167/246, 260/477

C07C 35/31 (2006.01) C07C 45/29 (2006.01) C07C 45/30 (2006.01) C07C 47/267 (2006.01) C07C 47/27 (2006.01) C07C 47/273 (2006.01) C07C 47/277 (2006.01) C07C 49/743 (2006.01) C07C 49/747 (2006.01) C07C 59/42 (2006.01) C07C 59/46 (2006.01) C07C 59/56 (2006.01) C07C 69/732 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1284654

ABSTRACT OF THE DISCLOSURE Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): Image Image Image (1) (2) (3) wherein: n is 2 or 3; R1 is CH20H, CHO, CO2R or CO2H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, Image optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 0,1 or 2; and R is Image wherein X is -?-CH3, -NH?CH3, -?-C6H5, -NH?-C6H5, or -NH?N(R4)2; in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

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