4-¬3-(1,2,3,4-tetrahydro-2-isoquinolyl)-2-...

Details 4-¬3-(1,2,3,4-tetrahydro-2-isoquinolyl)-2-... 4-¬3-(1,2,3,4-tetrahydro-2-isoquinolyl)-2-...

C - Chemistry, Metallurgy

07

D

260/277.35

C07D 413/06 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61K 31/475 (2006.01) C07D 217/00 (2006.01) C07D 217/04 (2006.01) C07D 217/16 (2006.01) C07D 271/00 (2006.01) C07D 271/06 (2006.01) C07D 273/04 (2006.01) C07D 401/06 (2006.01)

Patent

CA 1154019

ABSTRACT OF THE DISCLOSURE The invention concerns new compounds of the general formula (I) Image (I) wherein R1 is hydrogen, phenyl or phenyl substituted with one or more alkyl hav- ing 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro; R2 is alkyl having 1 to 4 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, phenyl, or phenyl substituted with one or more alkyl having 1 to 4 carbon atoms, haloyen, alkoxy having 1 to 4 carbon atoms or nitro; R3 is alkoxy having 1 to 4 carbon atoms or hydrogen; R is hydrogen, alkyl having 1 to 4 carbon atom optionally substituted with alkoxy having 1 to 4 carbon atoms, benzyloxy or cyano group, phenyl, or phenyl substituted with one or more alkyl haviny 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro, or a phenyl-(C1-4alkyl)-alkyl group, in which the phenyl moiety may bear an alkoxy substituent having 1 to 4 carbon atoms or a halogen; m and n represent 0, 1 or 2, and acid addition and quaternary salts thereof. The compounds are potent vasodilators and exert a favourcable influence on the extremital blood flow. They also show a heart function influencing activity. Methods for the preparation of said compounds and pharmaceutical oompositions containing them are also subject of the invention.

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