4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one...

Details 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one... 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one...

C - Chemistry, Metallurgy

07

D

C07D 207/26 (2006.01) A61K 31/4025 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2522631

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2- pyrrolidinone compounds. The compounds exhibit improved PDR4, inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula (I); wherein R1, R2, and R3 are as defined herein.

L'invention concerne l'inhibition sélective de la PDE4 à l'aide de composés de 4-(substitué-phényl)-2-pyrrolidinone. Ces composés permettent une inhibition améliorée de la PDR4 par rapport à des composés tels que le rolipram, et sont sélectifs en ce qui concerne l'inhibition d'autres classes de PDEs. Les composés de la présente invention sont représentés par la formule 1 dans laquelle R?1¿, R?2¿, et R?3¿ sont tels que définis dans les revendications.

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