4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(n,n-dimethylamino)...

Details 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(n,n-dimethylamino)... 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(n,n-dimethylamino)...

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2759063

The invention provides the compound 4-[(3-chloro-4- fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7- ((S)- tetrahydrofuran-3-yloxy)-quinazoline dimaleate. The compound may be used for treatment of a benign or malignant tumour, for preventing or treating a disease of the respiratory tract and lungs or for treating a disease of the gastro-intestinal tract, or the bile duct and gall bladder. The invention also provides a process for preparing a dimaleate of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1- oxo-2- buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline, comprising: converting 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-buten-1- yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline into the dimaleate by reacting with maleic acid in a suitable solvent, with heating.

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