4(3h)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives

Details 4(3h)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives 4(3h)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 471/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1301156

960-104/106 OUS 4(3H)-OXO-5,6,7,8-TETRAHYDROPYRIDO- [2,3-D]PYRIMIDINE DERIVATIVES ABSTRACT Derivatives of N-[4-(N-[2-amino-4(3H)-oxo- 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylmethyl- amino)benzoyl] L-glutamic acid are antineoplastic agents which can be prepared by hydrolysis of the corresponding compounds in which the 2-amino group and the glutamic acid carboxylic acid groups are protected.

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