4,5-diaryl-3(2h)-furanone derivatives as cyclooxygenase-2...

Details 4,5-diaryl-3(2h)-furanone derivatives as cyclooxygenase-2... 4,5-diaryl-3(2h)-furanone derivatives as cyclooxygenase-2...

C - Chemistry, Metallurgy

07

D

C07D 307/32 (2006.01) A61K 31/341 (2006.01) C07D 307/58 (2006.01) C07D 307/94 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 493/10 (2006.01)

Patent

CA 2369979

The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.

La présente invention concerne une nouvelle classe de dérivés de 4,5-diaryl-3(2H)-furanone, qui inhibent fortement et de manière sélective la COX-2 par rapport à la COX-1. Ces dérivés sont utiles pour traiter l'inflammation, des affections associées à l'inflammation et des maladies dépendant de COX-2.

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