4, 5-diarylthiazole derivatives as cb-1 ligands

Details 4, 5-diarylthiazole derivatives as cb-1 ligands 4, 5-diarylthiazole derivatives as cb-1 ligands

A - Human Necessities

61

K

A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 25/28 (2006.01) C07D 277/56 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2511603

The present invention relates to compounds of formula (I): in which R1 and R2 independently represent phenyl, thienyl or pyridyl and R3represents a group -X- Y-NR4R5 in which X is CO or SO2; Y is absent or represents NH and the other substituente are as defined in the description and their use in the treatment of obesity, psychiatric and neurological disorders and to pharmaceutical compositions containing them.

L'invention concerne des composés de formule générale (I), dans laquelle R?1 ¿et R?2 ¿représentent indépendamment phényle, thiényle ou pyridyle et R?3 ¿représente un groupe -X-Y-NR?4¿R?5¿ dans lequel X est CO ou SO¿2?; Y est absent ou représente NH, les autres substituants ayant la signification indiquée dans la description; leur utilisation dans le traitement de l'obésité, de troubles psychiatriques et neurologiques; ainsi que des compositions pharmaceutiques les contenant.

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