4,5-ring annulated indole derivatives for treating or...

Details 4,5-ring annulated indole derivatives for treating or... 4,5-ring annulated indole derivatives for treating or...

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/403 (2006.01) A61K 31/4427 (2006.01) A61K 31/4709 (2006.01) A61K 31/475 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61P 31/12 (2006.01) C07D 209/60 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 471/04 (2006.01) C07D 519/00 (2006.01) C07D 417/06 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2673254

The present invention relates to 4, 5 - ring annulated indole derivatives of formula ( I ), compositions comprising at leas t one 4, 5 - ring annulated indole derivatives, and methods of using the 4, 5 - ring annulated ^ndole derivatives for treating or preventing a viral inf ection or a virus - related disorder in a patient, (I) wherein ring Z of formula (I), is cyclohexyl, cyclohexenyl, 6-membered heterocycloalkyl, 6- membered heterocycloalkenyl, 6-membered aryl or 6-membered heteroaryl, wherein R1, R2, R3, R6. R7 and R10 are as described herein.

L'invention concerne des dérivés indole condensés à 4,5 noyaux de la formule (I), des compositions renfermant au moins un dérivé indole condensé à 4,5 noyaux, et des procédés d'utilisation des dérivés indole condensés à 4,5 noyaux dans le traitement ou la prévention d'une infection virale ou d'un trouble lié à un virus chez un patient, (I) le cycle Z de la formule (I) étant cyclohexyle, cyclohexényle, hétérocycloalkyle à 6 chaînons, hétérocycloalcényle à 6 chaînons, aryle à 6 chaînons ou hétéroaryle à 6 chaînons, où R1, R2, R3, R6, R7 et R10 sont tels que définis dans la description.

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