C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/4985 (2006.01) A61P 25/18 (2006.01)
Patent
CA 2653412
The invention relates to 4-amino-pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating diseases of mammals including a human which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 10 activity in the central nervous system. More particularly, the invention relates to the treatment of neurologic and psychiatric disorders, for example psychosis and disorders comprising cognitive deficits as symptoms.
L'invention concerne des 4-amino-pyrido[3,2-e]pyrazines, leurs méthodes de préparation, des préparations pharmaceutiques comprenant ces composés, et l'utilisation pharmaceutique de ces composés, qui sont des inhibiteurs de la phosphodiestérase 10, comme composés actifs destinés au traitement de maladies de mammifères, dont les êtres humains, maladies sur lesquelles les composés de l'invention peuvent agir par inhibition de l'activité de la phosphodiestérase 10 dans le système nerveux central. L'invention concerne plus particulièrement le traitement de troubles neurologiques et psychiatriques, tels que la psychose ou des troubles dont un des symptômes est le déficit cognitif.
Egerland Ute
Gasparic Antje
Hoefgen Norbert
Langen Barbara
Rundfeldt Chris
Elbion Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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