4-anilino-3-quinolinecarbonitriles for the treatment of...

Details 4-anilino-3-quinolinecarbonitriles for the treatment of... 4-anilino-3-quinolinecarbonitriles for the treatment of...

A - Human Necessities

61

K

A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2543163

Compounds of formula (I) wherein n is an integer from 1-3; X is N, CH, provided that when X is N, n is 2 or 3; R is alkyl of 1 to 3 carbon atoms; R1 is 2,4-diCI, 5-OMe; 2,4-diCI; 3,4,5-triOMe; 3-CI, 5-OMe; 2-Me, 5-OMe; 2,4-di- Me; 2,4-diMe-5-OMe, 2,4-diCI, 5-OEt; R2 is alkyl of 1 to 2 carbon atoms, and pharmaceutically acceptable salts thereof are useful for the treatment of chronic myelogenous leukemia (CML).

La présente invention concerne des composés représentés par la formule (I), dans laquelle, n représente un entier relatif compris entre 1-3; X représente N, CH, pour autant que lorsque X représente N, n représente 2 ou 3; R représente alkyle comprenant de 1 à 3 atomes de carbone; R?1¿ représente 2,4-diCI, 5-OMe; 2,4-diCI; 3,4,5-triOMe; 3-CI, 5-OMe; 2-Me, 5-OMe; 2,4-di-Me; 2,4-diMe-5-OMe, 2,4-diCI, 5-OEt; R?2¿ représente alkyle comprenant de 1 à 2 atomes de carbone, et des sels pharmaceutiquement acceptables, lesquels sont utilisés pour le traitement de la leucémie myéloïde chronique (CML).

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