4-aryl-3(5)-heteroaryl substituted pyrazoles as p38 kinase...

Details 4-aryl-3(5)-heteroaryl substituted pyrazoles as p38 kinase... 4-aryl-3(5)-heteroaryl substituted pyrazoles as p38 kinase...

C - Chemistry, Metallurgy

07

D

C07D 401/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2288741

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (I), wherein R1 and R2 are as described in the specification; and Ar1 is aryl optionally substituted with one or more radicals independently selected from halo, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkyldioxy, alkylthio, alkylsulfinyl, alkylsulfonyl, amino, aminocarbonyl, cyano, alkoxycarbonyl, formyl, aminosulfonyl, alkylamino, nitro, arylamino, alkylcarbonylamino, halosulfonyl, aminoalkyl, and haloalkyl; and HetAr2 is pyridinyl, pyrimidinyl or quinolinyl optionally substituted with one or more radicals independently selected from alkylthio, alkylsulfonyl, alkylsulfinyl, halo, alkyl, heterocyclyl, alkoxy, aralkoxy, haloalkyl, amino, cyano, aralkyl, alkylamino, cycloalkylamino, cycloalkenylamino, arylamino, alkynylamino, and aralkylamino; or a pharmaceutically-acceptable salt or a tautomer thereof.

La présente invention concerne une classe de dérivés de pyrazole destinés à traiter les troubles dont le médiateur est la kinase p38. Des composés présentant un intérêt particulier sont définis dans la formule (I) dans laquelle R?1¿, R?2¿, Ar?1¿ et HetAr?2¿ sont tels que définis dans la description.

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