4-aryl-3-aminoquinoline-2-one derivatives as potassium...

Details 4-aryl-3-aminoquinoline-2-one derivatives as potassium... 4-aryl-3-aminoquinoline-2-one derivatives as potassium...

A - Human Necessities

61

K

A61K 31/47 (2006.01) C07D 215/227 (2006.01) C07D 215/38 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2301549

The present invention provides novel 4-aryl-3-aminoquinolin-2-one derivatives having general formula (I), wherein R, R1, R2, R3, R4, R5 and R6 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulators of the large conductance calcium-activated K+ channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.

La présente invention concerne de nouveaux dérivés de 4-aryl-3-aminoquinoleïne-2-one de la formule générale (I) dans laquelle R, R?1¿, R?2, R?3¿, R?4¿, R?5¿ et R?6¿ sont comme définis ici; ou alors un sel de ces dérivés non toxique et acceptable du point de vue pharmaceutique. Les dérivés selon la présente invention sont des modulateurs des canaux K?+¿ à calcium activé à grande conductance et s'utilisent dans le traitement de troubles réceptifs à l'ouverture des canaux potassium.

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