4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/08 (2006.01) A61K 31/4178 (2006.01) A61K 31/422 (2006.01) A61K 31/4427 (2006.01) A61K 31/506 (2006.01) A61P 7/12 (2006.01) C07D 403/08 (2006.01) C07D 407/14 (2006.01) C07D 409/08 (2006.01) C07D 413/08 (2006.01) C07D 417/08 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2745969

The present invention comprises com-pounds of Formula (I). wherein: R1, R2, R3, and R4 are as defined in the specification. The invention also comprises pharmaceutical compositions comprising the compounds of formula (I) and methods of preventing, treating or ame-liorating a CCR2 mediated syndrome, disorder or disease, for example, type II diabetes, obesity or asthma, by admin-istering the compounds of formula (I).

La présente invention concerne les composés de formule (I) dans laquelle R1, R , R3 et R4 sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques comportant les composés de formule (I) et des procédés de prévention, de traitement ou d'amélioration d'un syndrome, d'une maladie ou d'un trouble médié par CCR2, par exemple les diabètes de type II, l'obésité ou l'asthme, par l'administration des composés de formule (I).

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