4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 231/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2524274

Disclosed are compounds of formulae (I) and (II) that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. Wherein Z is selected from O, S and NH; Q of formula (III) and the other substituents are as defined in claim 1.

L'invention concerne des composés de formule (I) et (II), qui sont des antagonistes du récepteur de la bradykinine de type B¿1?, et qui servent à traiter certaines maladies véhiculées par le récepteur de la bradykinine de type B1 ou à atténuer les symptômes négatifs de ces maladies chez les mammifères. Certains de ces composés sont très puissants et sont susceptibles d'exercer une action longue durée. Par ailleurs, Z est sélectionné parmi O, S et NH; Q est représenté par la formule (III) et les autres substituants sont tels que définis dans la revendication (1).

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