4'-demethyl-4-epipodophyllotoxin derivatives

C - Chemistry – Metallurgy – 07 – H

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260/230.58

C07H 17/04 (2006.01)

Patent

CA 1274510

ABSTRACT OF THE DISCLOSURE A 4'demethyl-4-epipodophylltoxin derivative of the for- mula: Image wherein R1 is a lower alkyl group; X1 and X2 are each a hydroxyl group or an amino group substituted by one or two lower alkyls, provided that either one of X1 and X2 is an amino group substi- tuted by one or two lower alkyls and the other is a hydroxyl group and pharmaceutically acceptable salts thereof which exhibit excellent anti-tumor activities.

505527

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