C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61P 5/28 (2006.01) A61P 5/34 (2006.01) C07J 13/00 (2006.01) C07J 75/00 (2006.01)
Patent
CA 2421302
The invention relates to 17-Methylene steroids. Method for the production thereof and pharmaceutical compositions containing these compounds. The inventive compounds have an active profile with a hybrid character of such that they act as inhibitors of the 5.alpha.-reductase and, at the same time, as gestagens. Said compounds are thus suited for treating medical disorders that, in men and women, are a result of an increased androgen level in certain organs and tissues. The inventive compounds combined with other hormonal substances such as estrogen, testosterone or a potent androgen are suited as contraceptives for women and men.
L'invention concerne des composés présentant un profil opérationnel à caractère hybride, de sorte à faire office d'inhibiteurs de la 5.alpha.-réductase et simultanément de gestagènes. Ils s'utilisent de ce fait pour traiter des affections, qui reflètent chez l'homme et la femme, une augmentation du taux d'androgènes dans des organes et des tissus déterminés. Associés à d'autres substances hormonales, telles qu'un oestrogène, de la testostérone ou un androgène puissant, lesdits composés s'utilisent comme contraceptifs chez la femme et chez l'homme.
Droescher Peter
Elger Walter
Hillisch Alexander
Kaufmann Gunter
Menzenbach Bernd
Jenapharm Gmbh & Co. Kg
Marks & Clerk
Schering Ag
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