4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 215/16 (2006.01) A61K 31/47 (2006.01) C07B 59/00 (2006.01) C07D 215/22 (2006.01)

Patent

CA 2156389

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions and inducing anesthesia are disclosed by administering to an amimal in need of such treatment a substituted or unsubstituted 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-one or pharmaceutically acceptable salts thereof which have high binding to the glycine receptor

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