C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 260/278
C07D 491/113 (2006.01) A61K 31/445 (2006.01) C07D 491/10 (2006.01) C07D 498/10 (2006.01)
Patent
CA 2023015
NOVEL 4-METHYLENE-2-OXO-8-AZASPIRO[4,5]DECANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME Abstract The invention relates to novel, therapeutically active 4-methylene-2-oxo-8-azaspiro[4,5]decane derivatives of the formula (I), Image (I) wherein X means oxygen or an Image group, wherein R stands for hydrogen, C1-12alkyl, C3-6cycloalkyl, carbocyclic C6-10aryl or carbocyclic C6-10aryl- C1-4alkyl group, the two latter ones being op- tionally substituted on their aromatic part by one or more, same or different halogen(s) or one or more C1-4alkyl group(s) or by one or more C1-4alk- oxy group(s); R3 and R4, which are the same or different, represent hydro- gen, one or more halogen(s), C1-4alkyl, C1-4alkoxy, trihalomethyl group or hydroxyl group optionally ester- ified by a C1-4alkanoic acid; and n is 1 or 2, their isomers, solvates, hydrates, acid addition and quater- nary ammonium salts. The invention further relates to pharmaceutical compo- sitions containing these compounds and a proces for their preparation. The compounds of the formula (I) possess antipsychotic properties. Thus, they are useful for the treatment of psy- chiatric disorders.
Auth Ferenc
Gaal Laszlo
Gorog Sandor
Groo Dora
Kiss Bela
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt.
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