4-(n-substituted amino)-2-butynyl-1-ureas and thioureas and...

Details 4-(n-substituted amino)-2-butynyl-1-ureas and thioureas and... 4-(n-substituted amino)-2-butynyl-1-ureas and thioureas and...

C - Chemistry, Metallurgy

07

C

167/208, 167/265

C07C 275/20 (2006.01) A61K 31/17 (2006.01) A61K 31/395 (2006.01) C07C 335/10 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01)

Patent

CA 2022510

ABSTRACT 4-(N-Substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.

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