4-oxo-1,4-dihydroquinoline m1 receptor positive allosteric...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 401/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) C07D 401/06 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2722577

The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

La présente invention concerne des composés de formule (I) qui sont des modulateurs allostériques positifs pour le récepteur M1 et qui sont utiles dans le traitement de maladies dans lesquelles le récepteur M1 est impliqué, telles que la maladie dAlzheimer, la schizophrénie, la douleur ou des troubles du sommeil. Linvention concerne en outre des compositions pharmaceutiques comprenant les composés, et lutilisation des composés et compositions dans le traitement de maladies médiées par le récepteur M1.

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