4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido...

Details 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido... 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2266849

In accordance with the present invention, there are provided 4-substituted-3- (2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives of formula (I), wherein n is 1, 2 or 3; in which R1, R2 and R3 are as defined herein, and salts thereof, which exhibit excellent cysteine proteinase inhibitory activity and which can be used for treatment of different diseases such as muscular dystrophy, myocardial infarction, bone resorption, arthritis, cancer metastasis, pulmonary emphysema, septic shock, cerebral ischemia, memory function, Alzheimer and cataract, malaria, glomerular basement membrane degradation, bacterial infection, inflammatory diseases, parasitic infections, and viral infections.

Dérivés de 3-(2-amino-2-cycloalkyle méthyle)-acétamido azétidine-2-one substituée en 4 de la formule (I) et leurs sels. Dans ladite formule, n est égal à 1, 2 ou 3; R¿1?, R¿2? et R¿3? sont tels que définis. Les produits en question offrent une excellente inhibition de cystéine protéinase, et on peut les utiliser pour le traitement de différentes maladies, à savoir par exemple: myopathie musculaire progressive, infarctus du myocarde, résorption osseuse, arthrite, métastases cancéreuses, emphysème pulmonaire, choc septique, ischémie cérébrale, fonction mnésique, maladie d'Alzheimer et cataracte, paludisme, dégradation de la membrane basale des capillaires du glomérule rénal, infection bactérienne, maladies inflammatoires, maladies parasitaires et infections virales.

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