4'-thionucleosides and oligomeric compounds

Details 4'-thionucleosides and oligomeric compounds 4'-thionucleosides and oligomeric compounds

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/116 (2006.01) A61K 39/38 (2006.01) C07K 1/00 (2006.01) C12P 1/02 (2006.01) C12P 21/04 (2006.01)

Patent

CA 2538252

The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.

L'invention porte sur des composés d'oligomères modifiés intervenant dans le mécanisme d'interférence de l'ARN dans la modulation de gènes. Lesdits composés comportent de l'ARNsi et de l'ARNas présentant au moins une modification d'affinité.

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