5-[(2r)-[2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]...

Details 5-[(2r)-[2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]... 5-[(2r)-[2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]...

C - Chemistry, Metallurgy

07

C

C07C 311/39 (2006.01) A61K 9/08 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/18 (2006.01) A61P 13/08 (2006.01) C07C 303/40 (2006.01)

Patent

CA 2668124

5-[(2R)-[2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2-methoxybenzenesulfonamide, a pharmaceutical composition containing the compound, and the synthesis method thereof. The compound has strong antagonism toward .alpha.1-adrenoceptor and has high selectivity toward smooth muscle of urethra.

La présente invention concerne un composé 5-[(2R)-[2-[2-[2-(2,2,2-trifluoroéthoxy)phénoxy]éthyl]amino]propyl]-2-methoxybenzenesulfonamide, une composition pharmaceutique contenant le composé, et son procédé de synthèse. Le composé présente un fort antagonisme vis-à-vis de l'adrénorécepteur .alpha.1 et présente une grande sélectivité vis-à-vis du muscle lisse de l'urètre.

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