5,6-dihydro-4-hydroxy-2-pyranones as hiv aspartyl protease...

Details 5,6-dihydro-4-hydroxy-2-pyranones as hiv aspartyl protease... 5,6-dihydro-4-hydroxy-2-pyranones as hiv aspartyl protease...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/35 (2006.01) C07D 309/32 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2339275

The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

Cette invention a trait à de nouvelles dihydropyrones à hétérocycles captifs. Ces substances, qui témoignent de propriétés pharmaceutiques améliorées, inhibent efficacement l'aspartyle protéase du VIH, bloquant l'infectivité du VIH. Ces dihydropyrones entrent dans la mise au point de thérapies visant à traiter des infections virales et des maladies à virus, le syndrome d'immunodéficience acquise notamment. L'invention porte également sur des procédés de synthèse des dihydropyrones ainsi que d'intermédiaires des plus utiles dans la préparation des composés finaux.

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