5-aza-7-deazapurine derivatives for treating infections with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/437 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 31/53 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2571675

This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-flavivirus or anti- pestivirus, biologically active compound has a 5-aza-7-deazapurine moiety. The 5-aza-7-deazapurine moiety may be substituted or unsubstituted, and may comprise a non-nucleoside or nucleoside analogue, or a salt or prodrug thereof. The compound of the present invention may be administered alone or in combination with another anti-hepatitis C, anti-flavivirus and/or anti- pestivirus agent.

L'invention concerne un procédé de traitement d'un hôte, en particulier d'un humain, infecté par l'hépatite C, un flavivirus et/ou un pestivirus, qui consiste à administrer à cet hôte une dose efficace d'un composé actif sur le plan biologique, anti-flavivirus ou anti-pestivirus, qui comprend un fragment de 5-aza-7-déazapurine. Le fragment de 5-aza-7-déazapurine peut être substitué ou non substitué, et peut comprendre un analogue nucléoside ou non nucléoside, ou un sel ou un promédicament de celui-ci. Le composé de l'invention peut être administré seul ou en combinaison avec un autre agent anti-hépatite C, anti-flavivirus et/ou anti-pestivirus.

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