5-carbamoylthieno (2,3-b)thiophene-2-sulfonamides as...

Details 5-carbamoylthieno (2,3-b)thiophene-2-sulfonamides as... 5-carbamoylthieno (2,3-b)thiophene-2-sulfonamides as...

C - Chemistry, Metallurgy

07

D

167/211, 167/242

C07D 495/04 (2006.01) A61K 31/38 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2009520

111/EWM1 17710 TITLE OF THE INVENTION 5-CARBAMOYLTHIENO[2,3-b]THIOPHENE-2-SULFON- AMIDES AS TOPICALLY ACTIVE CARBONIC ANHYDRASE INHIBITORS AND PROCESSES FOR PREPARATION ABSTRACT Novel 5-carbamoylthieno[2,3-b]thiophene- 2-sulfonamides and derivatives thereof are prepared in reactions of 5-methoxycarbonylthieno- [2,3-b]thiophene-2-sulfonamide with alkylamines, alkoxyalkylamines and hydroxyalkylamines. These compounds are useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.

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