5'-deoxy-cytidine derivatives

Details 5'-deoxy-cytidine derivatives 5'-deoxy-cytidine derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2237368

Novel 5'-deoxy-cytidine derivatives represented by the general formula (I) (see formula I) wherein R1 is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R2 is a hydrogen atom, or -CO-OR4 group [wherein R4 is a saturated or unsaturated, straight or branched hydrocarbon group consisting of one to fifteen carbon atoms, or a group of the formula -(CH2)n-Y (in which Y is cyclohexyl or phenyl; n is an integer from 0 to 4)]; R3 is a hydrogen atom, bromo, iodo, cyano, a C1-4 alkyl group [which may be substituted with halogen atom(s)], a vinyl or ethynyl group [which may be substituted with halogen atom(s), C1-4 alkyl, cycloalkyl, aralkyl, or aromatic ring which may have one or more hetero atom(s)], or an aralkyl group which may be substituted for use in medical therapy, especially tumor therapy.

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