5-(e)-bromovinyl uracil analogues and related pyrimidine...

A - Human Necessities – 61 – K

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A61K 31/505 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2378370

The present invention relates to pyrimidine nucleoside compounds and their use to treat viral infections of Varicella Zoster Virus, Epstein Barr Virus and Kaposi's Sarcoma virus, also known as HV- 8 and related complications of these viral infections. In another aspect of the present invention, the use of one or more nucleoside compound to increase the retention or half-life of 5-fluorouracil (FU) in patients is also described.

La présente invention concerne des composés nucléoside pyrimidine et leur utilisation pour le traitement des infections virales du virus varicelle-zona, du virus Epstein Barr, et du virus du sarcome de Kaposi, également connu sous le nom de HV-8, et les complications associées à ces infections virales. Un second aspect de la présente invention concerne l'utilisation d'un ou de plusieurs composés nucléosides afin d'augmenter la rétention ou la demi-vie du 5-fluoro-uracile (FU) chez les patients.

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