5-heteroaryl substituted indazoles as kinase inhibitors

Details 5-heteroaryl substituted indazoles as kinase inhibitors 5-heteroaryl substituted indazoles as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2689117

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

L'invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables, où A, R1, R2, R3 et m sont définis dans la description. L'invention concerne également des procédés de préparation desdits composés ainsi que des compositions contenant lesdits composés servant à inhiber les kinases telles que la glycogène synthase kinase 3 (GSK-3), la Rho kinase (ROCK), les Janus kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurore, pim 1 et nek 2.

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