5-nitrobenzo [de] isoquinoline-1.3-diones, their preparation...

Details 5-nitrobenzo [de] isoquinoline-1.3-diones, their preparation... 5-nitrobenzo [de] isoquinoline-1.3-diones, their preparation...

C - Chemistry, Metallurgy

07

D

167/211, 260/277

C07D 221/14 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 1331382

ABSTRACT OF THE DISCLOSURE: Disclosed are novel 5-nitrobenzo-[de]isoquinoline- 1,3-dione of the formula (I): Image (I) where n is 1 or 2, R1 and R2 are identical or different and are each hydrogen, C1-C6-alkyl, C1-C6-hydroxyalkyl, pyrrolidinyl, morpholino, piperidinyl or piperacinyl and R3 and R4 are identical or different and are each hydrogen, C1-C6-alkyl, C1-C6-acyl, C2-C7-alkoxycarbonyl, ureyl, amino- carbonyl or C2-C7-alkylaminocarbonyl, and its salts with physiologically tolerated acids. These derivatives are suitable for the treatment of diseases, especially du to their anti-tumor properties.

549722

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