C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/18 (2006.01) A61K 31/435 (2006.01)
Patent
CA 2116680
-21- PCT/CS92/00026 Abstract 6-[X-(2-HYDROXYETHYL)AMINOALKYL]-5,11-DIOXO-5,6-DIHYDRO- 11-H-INDENO[1,2-o]ISOQUINOLINES AND THEIR USE AS ANTINEOPLASTIC AGENTS New 6-[X-(2-hydroxyethyl)aminoalkyl] 5,11-dioxo-5,6-di- hydro-11H-indeno[1,2-c]isoquinolines represented by the general formula I Image (I) in which X stands for the number of carbon atoms from 0 to 5 in aminoalkyl group situated on nitrogen atom in position 6 of the indenoisoquinoline fundamental structure and their salts with inorganic and organic acids were described. Antitumorously effective indenoisoquinolines are most preferably prepared by the process in which the indeno[1,2-c]isocoumarine and/or 1-methoxy-2-(2-methoxycarbo- nylphenyl)-1-inden-3-one, respectively, comprises reacting with N-(hydroxyethyl)alkylen diamine in a medium of suitable aprotic solvent, preferably dimethylformamide, and at increased temperature. Another process for the preparation comprises reacting 6-(X-chloroalkyl)-5,11-dioxo-5,6-dihydro- 11H-indeno[1,2-c]isoquinolines with 2-aminoethanol in suitable solvent, preferably dimethylformamide, in the presence of anhydrous potassium carbonate. New compounds, and their salts are useful for the preparation of drugs aad compositions for the treatment of malignant neoplasias in mammals.
Ferenc Milan
Hrbata Jiri
Hruby Milan
Kargerova Anna
Kejhova Irena
Sim & Mcburney
Vyzkumny Ustav Pro Farmacii A. Biochemii S.p.
LandOfFree
6((2-hydroxyethyl)amino alkyl)-5,11-dioxo-5,6-... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 6((2-hydroxyethyl)amino alkyl)-5,11-dioxo-5,6-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6((2-hydroxyethyl)amino alkyl)-5,11-dioxo-5,6-... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1813772