6-(acylaminoaryl)-3(2h)-pyridazinone derivatives, their...

Details 6-(acylaminoaryl)-3(2h)-pyridazinone derivatives, their... 6-(acylaminoaryl)-3(2h)-pyridazinone derivatives, their...

C - Chemistry, Metallurgy

07

D

260/264.1, 260/2

C07D 237/00 (2006.01) C07D 237/04 (2006.01) C07D 237/14 (2006.01) C07D 237/26 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1229597

ABSTRACT OF THE DISCLOSURE: This invention relates to the preparation of novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula Image (I) where the substituents on the phenylene radical are meta or para to one another, A and B are each hydrogen or together form a bond, R1 and R2 are each hydrogen or C1-C3-alkyl, or, where A and B are hydrogen, together form a C1-C4-alkylene radical, R3 is straight-chain C1-C4 alkylene which can be substituted by 1 or 2 C1-C5-alkyl groups, and R4 is a) pyrrol-1-yl, imidazol-1-yl, pyrazol-1-yl of 1,2,4- triazol-1-yl, or b) a group of the formula II Image (II) c) a group of the formula III Image (III) d) a group of the formula IV -NR10R11 (IV) e) a group of the formula V Image (V) f) a group of the formula VI Image (VI) These compounds inhibit thrombocyte aggregation and gastric secretion and have hypotensive and positively inotropic properties.

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