C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2625502
The invention concerns compounds of formula (I), wherein: R1 represents a hydrogen atom or a C1-C4 alkyl group, CN, CF3 or CHF2; R2 represents a hydrogen atom or a C1-C4 alkyl group; R3 represents an unsubtituted or substituted phenyl; R4 represents a heterocyclic radial; R5 represents a hydrogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group. The invention also concerns a method for preparing said compounds and the therapeutic use thereof.
La présente invention a pour objet des composés répondant à la formule (I) : Formule (I) dans laquelle :- R1 représente un atome d'hydrogène ou un groupe (C1-C4) alkyle, CN, CF3 ou CHF2 ;- R2 représente un atome d'hydrogène ou un groupe (C1-C4) alkyle ; - R3 représente un phényle non substitue ou substitue ; - R4 représente un radical hétérocyclique; - R5 représente un atome d'hydrogène, un atome d'halogène, un groupe (C1-C4) alkyle, un groupe (C1-C4) alcoxy ; Procédé de préparation et application en thérapeutique.
Bourrie Bernard
Casellas Pierre
Ciapetti Paola
Derocq Jean-Marie
Jegham Samir
Robic
Sanofi Aventis
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