C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/00 (2006.01) C07D 211/44 (2006.01) C07D 211/54 (2006.01) C07D 211/72 (2006.01) C07D 215/10 (2006.01) C07D 413/00 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2533554
The present invention relates to compounds of the Formula wherein R1, R1a, R1b, R2,, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X, Y, W, U, Z, m and n are as definited. Compounds of the Formula (I) have activity inhibiting production of A.beta.-peptide. This invention also relates to pharmatical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer~s disease, in a mammal comprising compounds of the Formula (I).
La présente invention concerne des composés de formule (I) dans laquelle R?1, ¿R?1a, ¿R?1b¿, R?2,¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?11¿, R?12¿, X, Y, W, U, Z, m et n sont tels que définis. Les composés de formule (I) présentent une activité d'inhibition de la production de peptide .beta.A. La présente invention concerne également des compositions pharmaceutiques et des procédés pour traiter des maladies chez un mammifère, par exemple des maladies neurodégénératives telles que la maladie d'Alzheimer, impliquant des composés de formule (I).
Pfizer Products Inc.
Torys Llp
LandOfFree
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