C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/16 (2006.01) A61K 31/724 (2006.01) A61P 21/02 (2006.01)
Patent
CA 2390463
Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6)alkylene, optionally substituted with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p- ; o and p are independently 0-4; X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2-CH2-O)q-H, OH or tetrazol-5-yl; R1 is H or (C1-3)alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.
L'invention concerne un dérivé de 6-mercapto-cyclodextrine représenté par la formule (I) dans laquelle m est 0-7 et n est 1-8 et m+n = 7 ou 8; R représente alkylène C1-6 éventuellement substitué par des groupes 1-3 OH ou (CH2)o-phénylène-(CH2)p-; o et p sont indépendamment 0-4; X représente COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2-CH2-O)q-H, OH ou tétrazol-5-yl; R1 représente H ou alkyle C1-3; R2 représente carboxyphényle; q est 1-3; ou leurs sels acceptables sur le plan pharmaceutique. Ce dérivé de 6-mercaptocyclodextrine peut être utilisé avantageusement afin d'inverser le blocage neuromusculaire induit par des substances médicamenteuses.
Bennett David Jonathan
Palin Ronald
Zhang Mingqiang
Akzo Nobel N.v.
Fetherstonhaugh & Co.
N.v. Organon
LandOfFree
6-mercapto-cyclodextrin derivatives: reversal agents for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 6-mercapto-cyclodextrin derivatives: reversal agents for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-mercapto-cyclodextrin derivatives: reversal agents for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1445380