C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 3/04 (2006.01) A61P 25/20 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2460051
The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9- tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
L'invention concerne des dérivés de 7,8,9,10-tétrahydro-6<i>H</i>-azépino, 6,7,8,9-tétrahydro-pyrido et 2,3-dihydro-2<i>H</i>-pyrrolo[2,1-b]-quinazolinone représentés par la formule (I) et leur utilisation comme principe actif dans la préparation de compositions pharmaceutiques. L'invention concerne également des aspects connexes dont des procédés de préparation des composés, des préparations pharmaceutiques renfermant un ou plusieurs de ces composés et en particulier leur utilisation comme antagonistes des récepteurs de l'orexine.
Aissaoui Hamed
Clozel Martine
Fischli Walter
Koberstein Ralf
Sifferlen Thierry
Actelion Pharmaceuticals Ltd.
Gowling Lafleur Henderson Llp
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