7 .alpha. methoxycephalosporin derivatives

Details 7 .alpha. methoxycephalosporin derivatives 7 .alpha. methoxycephalosporin derivatives

C - Chemistry, Metallurgy

07

D

260/102

C07D 501/24 (2006.01) C07C 323/48 (2006.01) C07D 261/10 (2006.01) C07D 261/12 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1060432

ABSTRACT 7.alpha.-Methoxycephalosporin derivatives of formula (I): Image ( I) (in which: A represents an acetoxy group, a carbamoyloxy group or a (1-methyl-1H-tetrazol-5-yl)thio group; and Y represents a cyanomethylthio group, a 1-cyanoethylthio group, a propargylthio group, an azidomethylthio group, a 2-hydroxyethylthio group, a 3-isoxazolyloxy group, a 3-isoxazolylthio group, a methylsulphonyl group, an ethylsulphonyl group, a 2-cyanoethylsulphonyl group or a sydnon-3-yl group) and pharmaceutically acceptable salts thereof are useful as antibacterial agents, nutritional supplements for animal feeds and therapeutic agents. These compounds may be prepared by reacting the corresponding 7.beta.-amino-7.alpha.- methoxycephalosporin derivative with the corresponding substituted acetic acid, or functional derivative thereof, or, where A represents a (1-methyl-1H-tetrazol- 5-yl)thio group, they may be prepared by reacting a compound of formula (I) in which A represents an acetoxy group or a carbamoyloxy group with 5-mercapto-1-methyl-1H-tetrazole or an alkali metal salt thereof.

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