A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/425 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07D 417/08 (2006.01)
Patent
CA 2532102
The present invention is directed to compounds of the formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R16 are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿ et R?16¿ sont définis dans la description. Ces composés sont utiles en tant que modulateurs de l'activité des récepteurs de chimiokines. En particulier, ces composés sont utiles en tant que modulateurs du récepteur de chimiokines CCR-2.
Ge Min
Goble Stephen D.
Pasternak Alexander
Yang Lihu
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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