7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-...

Details 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-... 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01) C07D 471/04 (2006.01) C07D 498/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2099591

7-Substituted-6-fluor-1,4-dihydro-4-oxo-quinoline-, naphthyridine- and benzoxazine carboxylic acids of formula (1), wher- ein R1 is a cycloalkyl group or a phenyl group which may be substituted by one or two halogen atoms; R2 is hydrogen, a ha- logen atom, an alkyl group, a hydroxy group or an amino group; R3 is hydrogen, hydroxy or amino; R4 is a 1,2,3-triazol- 1-yl group, a 1,2,4-triazol-1-yl group, a 1,2,3,4-tetrazol-1-yl or a 1,2,3,4- tetrazol-2-yl group, each of which may have 1 to 2 substituents selected from the group consisting of alkyl, COOH, CH2NH2, amino and phenyl groups; and x is N, CH, C-F or C-OCH3; n is 0, 1 or 2; or (II) may be (III), are described, as well as a process for their preparation and their use as an- tibacterial agents.

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