8,10-dideazaminopterins

C - Chemistry – Metallurgy – 07 – D

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260/242.5

C07D 471/04 (2006.01)

Patent

CA 1233176

10-ALKYL-8,10 DIDEAZAMINOPTERINS Abstract 10-Alkyl-8,10-dideazaminopterins of the formula Image where R is alkyl of 1 to about 8 carbon atoms and their carboxylate and acid addition salts are described. These compounds exhibit antineoplastic activity that is similar to, but more effective than, methotrexate.

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