8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2462806

The invention relates to compounds of formula (I), wherein R1 is -NR'R", wherein R' and R" are independently from each other lower alkyl, -(CH2)n- C(O)NRaRb, -(CH2)n-heteroaryl, -(CH2)n-aryl, -(CH2)n-CN, -(CH2)n-O-lower alkyl or -(CH2)n-cycloalkyl, or R'and R" form together with the N-atom a five or six- membered none aromatic ring, which may contain one additional O or S heteroatom, and whose rings may be unsubstituted or substituted by one or two substituents, selected from the group consisting of lower alkyl, -C(O)NRaRb or -(CH2)n-O-lower alkyl and RaRb are independently from each other hydrogen or lower alkyl; R2 is aryl or heteroaryl, unsubstituted or substituted ba lower alkyl or halogen; n is 0, 1, 2 or 3; and to their pharmaceutically acceptable salts. The compounds may be used in the treatment of diseases, associated with the adenosime A2 receptor.

La présente invention se rapporte à des composés de la formule (1) dans laquelle R?1¿ est -NR'R", où R' et R" sont indépendamment l'un de l'autre alkyle inférieur, -(CH¿2?)¿n?-C(O)NR¿a?R¿b?, -(CH¿2?)¿n?-hétéroaryle, -(CH¿2?)¿n?-aryle, -(CH¿2?)¿n?-CN, -(CH¿2?)¿n?-O-alkyle inférieur ou -(CH¿2?)¿n?-cycloalkyle, ou R'et R" forment ensemble avec l'atome N un cycle non aromatique à cinq ou six chaînons, qui peut contenir un hétéroatome supplémentaire O ou S, et dont les noyaux peuvent être non substitués ou substitués par un ou deux substituants, choisis dans le groupe composé de l'alkyle inférieur, de -C(O)NR¿a?R¿b? ou -(CH¿2?)¿n?-O-alkyle inférieur, et R¿a?R¿b? sont indépendamment l'un de l'autre hydrogène ou alkyle inférieur ; R?2¿ est aryle ou hétéroaryle, non substitué ou substitué par un alkyle inférieur ou un halogène; n est 0, 1, 2 ou 3; et à leurs sels pharmaceutiquement acceptables. Les composés de l'invention peuvent être utilisés dans le traitement de maladies, associés au récepteur A2 de l'adénosine.

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