C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61P 1/10 (2006.01)
Patent
CA 2646409
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I) wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
La présente invention concerne de nouveaux composés de 8-azabicyclo[3.2.1]octane de formule (I) où R1, R2, R3, A et G sont tels que définis dans la description, ou un sel ou solvate pharmaceutiquement acceptable de ceux-ci, lesdits composés étant des antagonistes du récepteur opioïde mu. L'invention décrit également des compositions pharmaceutiques contenant de tels composés, des procédés d'utilisation de tels composés visant à traiter des pathologies associées à l'activité du récepteur opioïde mu, ainsi que des procédés et des intermédiaires utiles pour la préparation de ces composés.
Church Timothy J.
Dalziel Sean
Jacobsen John R.
Jiang Lan
Long Daniel
Theravance Inc.
Torys Llp
LandOfFree
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