8-hydroxy substituted adenine compounds and uses thereof

Details 8-hydroxy substituted adenine compounds and uses thereof 8-hydroxy substituted adenine compounds and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01) A61K 31/522 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 473/16 (2006.01) C07D 473/24 (2006.01) C07D 473/34 (2006.01) C07D 473/40 (2006.01)

Patent

CA 2497765

A drug for topical administration which is effective as an antiallergic agent. The drug for topical administration contains as an active ingredient either an adenine compound represented by the general formula (1): (1) [wherein ring A represents a 6- to 10-membered, mono- or bicyclic, aromatic carbocycle or a 5- to 10-membered, mono- or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among zero to two nitrogen atoms, zero or one oxygen atom, and zero or one sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least either of Q1 and Q2 represents -COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

L'invention concerne un médicament topique efficace comme agent antiallergique. Ce médicament topique renferme, comme ingrédient actif, un composé d'adénine représenté par la formule générale (1) [dans laquelle le cycle A désigne un carbocycle aromatique mono- ou bicyclique comportant 6 à 10 éléments ou un hétérocycle aromatique mono- ou bicyclique comportant 5 à 10 éléments contenant un à trois hétéroatomes sélectionnés dans le groupe renfermant zéro à deux atomes d'azote, zéro ou un atome d'oxygène, et zéro ou un atome de soufre ; n désigne un entier compris entre 0 et 2 ; m désigne un entier compris entre 0 et 2 ; R désigne un halogéno, un alkyle (non) substitué, etc. ; X?1¿ désigne de l'oxygène, du soufre, NR?1¿ (R?1¿ désignant de l'hydrogène ou un alkyle), ou une liaison simple ; Y?1¿ désigne une liaison simple, un alkylène, etc. ; Y?2¿ désigne une liaison simple, un alkylène, etc. ; Z désigne un alkylène ; et au moins un des Q?1¿ et Q?2¿ désigne COOR?10¿ (R?10¿ désignant un alkyle (non) substitué, etc.), etc.] ou un sel de qualité pharmaceutique de ce composé.

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